Invited letter concerning: Complement activation caused by different oxygenators
نویسندگان
چکیده
منابع مشابه
Effect of Serum Precoat on Complement Activation in Membrane Oxygenators: An In Vitro Study
-----------------Previous studies have shown that extracorporeal circulation devices can activate the complement cascade via the alternative pathway. Anaphylatoxins (C3a and C5a) generated by complement activation may lead to pulmonary leukocyte sequestration, pulmonary edema, granulocytopenia and microvascular lung damage. This is of particular concern in patients on cardiopulmonary bypass. Th...
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____________ _ Complement activation induced by latex, polyvinylchloride, and silicone tubings for extracorporeal circulation was studied in 2 in vitro situations: Fresh whole human blood mixed with priming solution was circulated through 1 00 em tubing lengths for 1 hour, and small tubing pieces were incubated in fresh human serum for 7 hours. Activation of C3 and of the terminal pathway (C5-C...
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Extracorporeal removal of low-density lipoprotein (LDL) cholesterol by means of selective LDL apheresis is indicated in otherwise uncontrolled familial hypercholesterolemia. During blood-biomaterial interaction other constituents than the LDL particles are affected, including the complement system. We set up an ex vivo model in which human whole blood was passed through an LDL apheresis system ...
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We have read with great interest the article by Kadoch and colleagues (1). Their pharmacokinetic model indicates rapid distribution of intraventricular rituximab from cerebrospinal fluid (CSF) into neural tissues and serum. These findings may have more general implications for intrathecal (IT) immunotherapy with monoclonal antibodies. IT trastuzumab was safe and effective in HER2-positive lepto...
متن کاملIn vitro variability in fentanyl absorption by different membrane oxygenators.
The membrane oxygenator has replaced the bubble oxygenator in a wide variety of clinical settings. The membrane oxygenators now manufactured can be grouped into three categories based on composition and design: (1) silicone with a true membrane structure; (2) polypropylene with a microporous sheet; and (3) polypropylene with a microtubular structure. The capacity for fentanyl uptake by membrane...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 1989
ISSN: 0022-5223
DOI: 10.1016/s0022-5223(19)34427-7